Autoantibodies in COVID‐19 correlate with antiviral humoral responses and distinct immune signatures

• DOI: 10.1111/all.15302
• Publication Date: 2022-04-01T21:11:01Z
• Authors: Patrick Taeschler; Carlo Cervia; Yves Zurbuchen; Sara Hasler; Christian Pou; Ziyang Tan; Sarah Adamo; Miro E. Raeber; Esther Bächli; Alain Rudiger; Melina Stüssi‐Hel...; Lars C. Huber; Petter Brodin; Jakob Nilsson; Elsbeth Probst‐Mü...; Onur Boyman
• Keywords: 0301 basic medicine; 2403 Immunology; 0303 health sciences; SARS-CoV-2; Immunology; COVID-19; 610 Medicine & health; Antiviral Agents; Antibodies, Antineutrophil Cytoplasmic; Immunity, Humoral; 3. Good health; 03 medical and health sciences; Antibodies, Antinuclear; 10033 Clinic for Immunology; 2723 Immunology and Allergy; Immunology and Allergy; Humans; ORIGINAL ARTICLES; Autoantibodies

Several autoimmune features occur during coronavirus disease 2019 (COVID-19), with possible implications for course, immunity, and pathology. In this study, we longitudinally screened clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, association comorbidities, severity of COVID-19.We performed highly sensitive indirect immunofluorescence assays detect antinuclear antibodies (ANA) antineutrophil cytoplasmic (ANCA), along serum proteomics virome-wide serological profiling in a multicentric cohort 175 COVID-19 patients followed up 1 year after infection, eleven vaccinated individuals, 41 unexposed controls.Compared healthy controls, similar prevalence patterns ANA were present acute recovery. However, the paired analysis revealed subgroup transient presence certain COVID-19. Furthermore, severe exhibited high ANCA disease. These quantitatively associated higher SARS-CoV-2-specific antibody titers thus linking autoantibody production increased antigen-specific humoral responses. Notably, qualitative breadth cross-reactive other coronaviruses was comparable ANA-positive ANA-negative individuals autoantibody-positive patients, multiparametric characterization demonstrated an inflammatory signature alterations B-cell compartment recovery.Highly SARS-CoV-2 while correlated antiviral immune responses signatures.