Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

• DOI: 10.1111/all.15961
• Publication Date: 2023-11-28T06:25:51Z
• Authors: Sevim Bavbek; Seçil Kepil Özdemir; Patrizia Bonadonna; Marina Atanaskovi...; Annick Barbaud; Knut Brockow; Jose Laguna Martinez; Alla Nakonechna; Mauro Pagani; Alessandra Arcolacı; Carla Lombardo; Maria J. Torres
• Keywords: Drug Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Humans; Proton Pump Inhibitors; 3. Good health; Skin Tests

AbstractProton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well‐known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%–3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence‐based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in‐depth investigations in the topic.