Multimodal profiling of biostabilized human skin modules reveals a coordinated ecosystem response to injected mRNA‐1273 COVID‐19 vaccine

• DOI: 10.1111/all.16273
• Publication Date: 2024-08-19T09:25:28Z
• Authors: Manon Scholaert; Mathias Peries; Emilie Braun; Jeremy Martin; Nadine Serhan; Alexia Loste; Audrey Bruner; Lilian Basso; Benoît Chaput; Eric Merle; Pascal Descargues; Emeline Pagès; Nicolas Gaudenzio
• Keywords: Profiling (computer programming); Drug Development

Abstract Background The field of drug development is witnessing a remarkable surge in the innovative strategies. There need to develop technological platforms capable generating human data prior progressing clinical trials. Methods Here we introduce new flexible solution designed for comprehensive monitoring natural skin ecosystem's response immunogenic drugs over time. Based on unique bioengineering preserve surgical resections long survival state, it allows first time analysis resident immune cells at both organ and single‐cell levels. Results Upon injection mRNA‐1273 COVID‐19 vaccine, characterized precise sequential molecular events triggered upon detection exogenous substance. vaccine consistently targets DC/macrophages mast cells, regardless administration route, while promoting specific cell–cell communications surrounding cell subsets. Conclusion Given its direct translational relevance, this approach provides multiscale vision genuine tissue immunity that could pave way toward vaccination