Effects of long‐term paroxetine or bupropion treatment on puberty onset, reproductive and feeding parameters in adolescent male rats

• DOI: 10.1111/and.13268
• Publication Date: 2019-03-15T07:25:51Z
• Authors: Ahmet Yardimci; Nazife Ulker; Ozgur Bulmus; Nalan Kaya; Neriman Colakoglu; Mete Ozcan; Sinan Canpolat; Haluk Kelestimur
• Keywords: Paroxetine; Bupropion

Antidepressant use in adolescents has become more common recent years. We have found several studies stating that prenatal antidepressant exposure can lead to delayed or earlier puberty onset but there was no study on postnatal paroxetine bupropion. The main aim of this investigate the effect bupropion onset, reproductive and feeding results. male rats (n = 8/group) aged 21 days were exposed (3.6 mg/kg) (17 orally by gastric gavage every day from 21-90. Also, control group received only saline as a vehicle. Postnatal compared group, it not significant. Sperm counts significantly lower groups group. motility In addition, sperm histopathological examination, damage testicular structure both treatments. Taken together, our result indicates may affect contribute impairment fertility rats.