Achillea millefolium alleviates testicular damage in paclitaxel‐intoxicated rats via attenuation of testicular oxido‐inflammatory stress and apoptotic responses

• DOI: 10.1111/and.14028
• Publication Date: 2021-03-02T12:59:52Z
• Authors: Ufuk Okkay; Irmak Ferah Okkay; Betul Cicek; Ismail Cagri Aydin; Muhammed Sait Ert...; Cemil Bayram; Selcuk Senyayla; Selma Sezen; Ali Sefa Mendil; Leyla Guven; Ahmet Hacimuftuoglu
• Keywords: Achillea millefolium; Malondialdehyde

The aim of this study was to investigate the effects Achillea millefolium extract in paclitaxel-induced testicular toxicity rats. groups were designed as (1) control, (2) paclitaxel (8 mg/kg, intraperitoneally), (3) intraperitoneally) + (200 orally for 14 consecutive days) and (4) (400 days). Serum levels testosterone, luteinising hormone follicle-stimulating hormone, well total antioxidant capacity oxidant status measured one day after receiving last dose extract. Testicular superoxide dismutase activity, malondialdehyde, tumour necrosis factor alpha interleukin-1β levels, expressions nuclear kappa B caspase-3 evaluated. In addition, sections evaluated histopathologically 8-hydroxy-2′-deoxyguanosine detected immunohistochemically. improved upregulated enzymes downregulated inflammation. Furthermore, we observed that restored histopathological structure significantly suppressed oxidative DNA damage apoptosis by reducing expression caspase-3. Taken together, our results suggest has protective against is a promising natural product with potential improve male fertility.