Prevalence and determinants of radiological vertebral fractures in patients with Klinefelter syndrome

• DOI: 10.1111/andr.12841
• Publication Date: 2020-06-18T19:29:16Z
• Authors: Walter Vena; Alessandro Pizzocaro; Rita Indirli; Myriam Amer; Filippo Maffezzoni; Andrea Delbarba; Lorenzo Leonardi; Luca Balzarini; Fabio M. Ulivieri; Alberto Ferlin; Giovanna Mantovani; Andrea G. Lania; Emanuele Ferrante; Gherardo Mazziotti
• Keywords: FRAX; Osteopenia

Klinefelter syndrome (KS) may induce skeletal fragility, but the studies so far published on this topic were mainly focused evaluation of bone mineral density (BMD) and microstructure, whereas data fracture risk are still lacking.To evaluate prevalence determinants vertebral fractures (VFs), that is, hallmark osteoporosis, in subjects with KS.Eighty-seven patients KS (median age 41 years, range 18-64) consecutively evaluated for radiological VFs (by quantitative morphometry) lumbar spine femoral neck BMD DXA). Fifty-five also by assessment (FRAX) tool.Low was found 22/87 (25.3%) [12 osteopenia, three osteoporosis seven "low per age" (subject < 50 years Z-score ≤-2.0 SD)] 13/87 (14.9%) patients. In VFs, median deformity index 2 (range 1-9). Prevalence similar between healthy low-BMD (15.9% vs 13.6%; P = .80). Noteworthy, had significantly higher at diagnosis as compared to who did not (P .039), without significant differences time observation .162), body mass .234), testosterone replacement therapy .432), duration .409), vitamin D 681), serum levels .338). Moreover, more likely complain back pain comparison those (33.3% 7.4%; .047). 55 cases FRAX® tool, no 10-year major .270) hip .860) fractured non-fractured patients.This study provides first evidence be associated close relationship delay disease independently values or therapy.