A vascular approach to mild amnestic cognitive impairment: a pilot study

• DOI: 10.1111/ane.12054
• Publication Date: 2012-11-29T11:24:11Z
• Authors: A. Fromm; A. J. Lundervold; G. Moen; S. Skulstad; L. Thomassen
• Keywords: Male; Brain; Pilot Projects; Ultrasonography, Doppler; Comorbidity; Middle Aged; Neuropsychological Tests; Severity of Illness Index; Body Mass Index; 3. Good health; Cerebrovascular Disorders; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Humans; Cognitive Dysfunction; Female; Aged

Mild cognitive impairment (MCI) is a subtle memory disorder not matching criteria for dementia. There evidence vascular comorbidity in several types of We hypothesized that neurovascular workup would detect high degree disease patients with MCI.In cooperation our clinic, amnestic MCI were referred to department investigation. The encompassed ultrasound examination carotid duplex including Intima-Media-Thickness (IMT) measurement, and transcranial Doppler (TCD) one-hour microemboli monitoring, cerebrovascular reactivity measurement Bubble test. Cerebral MRI the evaluation white-matter lesions, brain atrophy, hippocampal volumes, amyloid angiopathy was performed.Ten included. Vascular risk factors present six patients. Four had atherosclerotic three classified as mild, one moderate stenosis. IMT > 1 mm found two patients, maximum 1.11 mm. None acceptable bone window intracranial stenosis TCD. Vasoreactivity pathologically low patient. Permanent right-left shunt which showed spontaneous cerebral microembolism. Hippocampal volume reduction cortical atrophy four Chronic ischemic changes patient, subcortical infarctions. Cortical infarctions, microbleeds, or found.Pure probably less associated may be more consistent evolving Alzheimer's disease. However, are common these