Decreased expression of Syndecan‐ 1 (CD138) in the endometrium of adenomyosis patients suggests a potential pathogenetic role

• DOI: 10.1111/aogs.15012
• Publication Date: 2024-11-21T05:10:02Z
• Authors: Walid Shaalan; Mohamed Gamal Ibr...; Ariana Plasger; Nourhan Hassan; Ludwig Kiesel; Andreas N. Schüring; Martin Götte
• Keywords: Adenomyosis; Myometrium

Abstract Introduction Adenomyosis is a special subtype of endometriosis, affecting the myometrium, about 20% women in reproductive age period. Clinical symptoms and intensity are diverse can vary from heavy menstrual bleeding dysmenorrhea to infertility repeated pregnancy losses. Thus, patients often present with long history illness pending presumptive clinical or surgical diagnosis. A definitive diagnosis adenomyosis made upon histopathological examination verifying ectopic endometrial tissue (endometrial glands and/or stroma) within surrounded by hyperplastic hypertrophic smooth muscles. However, nowadays ultrasonographic MRI signs precisely detect it as well. The precise etiology pathogenesis remain unclear. One theory assumes that occurs through metaplastic transformation migration stem cell‐like cells. Material Methods Our study examined immunohistochemical expression transmembrane proteoglycan Syndecan‐1 (CD 138), multifunctional matrix receptor signaling co‐receptor, endometrium 35 ( n = 21 14 control group) period 2016–2017. Results As pilot study, we concluded downregulated compared group, supporting its potential role development adenomyosis. did not find correlation between immune‐expression cycle phase. Conclusions For significance relation our results, investigated data showed downregulation adenomyotic may suggest promoting invasiveness endometriotic islands myometrium. further studies still needed understand mechanistic contribution