The Effect of On‐Line Hemodiafiltration, Vegetarian Diet, and Urine Volume on Advanced Glycosylation End Products Measured by Changes in Skin Auto‐Fluorescence

• DOI: 10.1111/aor.13143
• Publication Date: 2018-04-03T05:35:42Z
• Authors: Arkom Nongnuch; Andrew Davenport
• Keywords: Aged, 80 and over; Male; Diet, Vegetarian; Receptor for Advanced Glycation End Products; Urination; Hemodiafiltration; Middle Aged; 6. Clean water; Fluorescence; 3. Good health; Diet; 03 medical and health sciences; 0302 clinical medicine; Hemodialysis; Skin auto‐fluorescence; Humans; Residual urine volume; Female; Advanced glycosylation end products; Aged; Skin

Increasing urea clearance by hemodialysis (HD) has not improved patient survival. Hemodiafiltration (HDF) been reported to reduce cardiovascular mortality. HDF increases middle sized solute clearances. Advanced glycosylation end products (AGEs) are associated with increased We wished determine whether reduces AGEs. Skin auto-fluorescence (SAF) measures circulating AGEs deposited in the skin. compared SAF measurements 12 months apart high flux HD and patients. At enrollment was different (HD 3.34 ± 0.71 vs. 3.48 1.05 AU). seven after completion of measurement, one hemodiafiltration center returned hemodialysis, converted hemodiafiltration. In 66 patients treated solely HD, (3.36 3.82 0.88 AU, P < 0.001), whereas there no change for 47 exclusively (3.45 1.13 3.44 0.85 > 0.9). 34 switching from (3.52 0.94 3.88 1.05, 0.05), significant 33 converting (3.32 0.72 1.07 0.3). On multivariate analysis, older age (β coefficient 0.013, = 0.002), prescription insulin 0.29, 0.016), lanthanum 0.36, 0.004), warfarin 0.62, 0.012), vegetarian diet 250 mL/day residual urine volume were negatively -0.58, 0.002 β -0.26, 0.033 respectively). Residual output lower AGE deposition. Whereas over time statistical those HDF.