Extreme duration exercise affects old and younger men differently

• DOI: 10.1111/apha.13816
• Publication Date: 2022-03-29T08:54:37Z
• Authors: Jacob Frandsen; Ronni Eg Sahl; Tue Rømer; Mikkel Thunestved...; Andreas Blaaholm ...; Michelle Munk Lie...; Hanne Kruuse Rasm...; Ditte Søgaard; Arthur Ingersen; Mads Rosenkilde; Klaas Westerterp; Jens Juul Holst; Jesper Løvind And...; Adam Roman Markowski; Agnieszka Blachni...; Christoffer Clemm...; Massimo Sacchetti; Angelo Cataldo; Marcello Traina; Steen Larsen; Flemming Dela; Jørn Wulff Helge
• Keywords: Endurance Training

Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare wide range physiologic parameters in two cohorts seven trained men, age 30 ± 5 years or 65 6 years, before after participants travelled ≈3000 km by bicycle over 15 days.Over 15-day intervention, lost 2-3 kg fat mass with no significant change body weight. V̇O2 max did not cyclists, but decreased (p = 0.06) cohort. The resting plasma FFA concentration markedly both groups, glucose increased group. In cohort, LDL-cholesterol triglyceride decreased. skeletal muscle, transporters CD36 FABPm remained unchanged. handling proteins GLUT4 SNAP23 groups. Mitochondrial ROS production ADP sensitivity muscle cohort.In summary, these data suggest that experience negative affecting cardiovascular function extreme exercise, while positive same intervention is observed peripheral tissues men. results also thresholds differ old this difference primarily affects central functions men exercise.