CCL2 recruits T cells into the brain in a CCR2‐independent manner

• DOI: 10.1111/apm.12740
• Publication Date: 2017-08-24T12:49:05Z
• Authors: Oriane Cédile; Agnieszka Wlodarczyk; Trevor Owens
• Keywords: CXCR3; CCR2; CCL5; CCL17; CCR4

CCL2 is a chemokine that can be induced during neuroinflammation to recruit immune cells, but its role in the central nervous system (CNS) unclear. Our aim was better understand role. We CNS of naive CCL2-deficient mice using intrathecally administered replication-defective adenovirus and examined cell infiltration by flow cytometry. expression pronounced unexpected recruitment regulatory IFNγ-producing T cells from blood, possibly related defective egress monocytes bone marrow. Infiltration also occurred lacking CCR2, receptor for CCL2. Expression another CCL2, CCR4, CXCR3, CXCL10, which induced, were both increased CCL2-treated CNS. CCR4 expressed neurons astrocytes as well CD4 CXCR3 CD8 cells. Chemokine-recruited did not lead pathology. findings show redundancy among receptors ensures optimal response.