I148M variant of PNPLA3 increases the susceptibility to non‐alcoholic fatty liver disease caused by obesity and metabolic disorders

• DOI: 10.1111/apt.13521
• Publication Date: 2016-01-14T08:52:16Z
• Authors: M.‐F. Xia; Y. Ling; H. Bian; H.‐D. Lin; H.‐M. Yan; X.‐X. Chang; X.‐M. Li; H. Ma; D. Wang; L.‐S. Zhang; S.‐S. Wang; B.‐J. Wu; W.‐Y. He; N.‐Q. Zhao; X. Gao
• Keywords: Steatosis; Steatohepatitis

Summary Background The patatin‐like phospholipase 3 ( PNPLA 3) rs738409 gene polymorphism is an important genetic determinant of non‐alcoholic fatty liver disease NAFLD ). However, the associations between fat and metabolic traits in G allele carriers allelic influence on this association have not been fully studied. Aim To investigate with serum factors carotid atherosclerosis. Methods Liver was measured by quantitative ultrasound 4300 subjects Shanghai Changfeng community analysed for its obesity individuals CC , CG GG genotypes. Results Non‐alcoholic occurred 37.9% 28.8% genotypes respectively P < 0.001). significantly associated body mass index, waist circumference, triglycerides, high‐density lipoprotein cholesterol, fasting blood glucose insulin Compared homozygotes, homozygotes presented higher fibrosis scores despite their better status (comparison regression line slopes, 0.05). An increase accompanied a significant average maximum intima‐media thickness genotype but those genotype. Conclusions were found to be more susceptible metabolic‐related hepatic steatosis, developed presenting relatively statuses lower risks