Persistent damage on magnetic resonance enterography in patients with Crohn’s disease in endoscopic remission

• DOI: 10.1111/apt.15013
• Publication Date: 2018-10-22T08:26:57Z
• Authors: Jordi Rimola; Ignacio Alfaro; Agnès Fernández‐C...; Jesús Castro‐Poceiro; Daniel Vas; Sonia Rodríguez; Maria Carme Masamunt; Ingrid Ordás; Elena Ricart; Julián Panés
• Keywords: Crohn disease

Summary Background In Crohn's disease, it is essential to distinguish between persistent damage and abnormalities that can heal with anti‐inflammatory therapy. Aim To assess magnetic resonance enterography (MRE) lesions persist in patients long‐standing endoscopic remission, analyse their relationship baseline characteristics, determine prognostic implications. Methods We systematically reviewed pre‐ post‐treatment MRE findings disease severe inflammation (segmental CDEIS ≥ 7 or ulcers at least one segment) who achieved remission (CDEIS < 2) after 1 year of treatment TNF‐inhibitors autologous haematopoietic stem‐cell transplantation. Logistic regression analysis was used identify predictors abnormalities. Results Endoscopic 73 intestinal segments 28 (69% females; 9.95 years duration, 67.9% inflammatory phenotype; 39.3% ileal location). Creeping fat wall deposits were unchanged on despite the remission. Luminal strictures persisted 6 out 8 strictures, thickening 23 72 baseline. Predictors mural pre‐treatment thickness > 5.9 mm (OR = 4.38, P 0.027) refractory prior 2.35, 0.001). only predictor for persistence creeping 36.43, Persistence associated earlier recurrence ( 0.014). Conclusions Persistent are frequent achieving Significant thickening, deposition, signs established damage.