Afamin and Apolipoprotein F Associated With Liver Steatosis From People Living With HIV: A Discovery Study

• DOI: 10.1111/apt.70119
• Publication Date: 2025-04-01T04:53:49Z
• Authors: Mario Frías; Eduardo Chicano‐G...; Antonio Rivero‐Ju...; Ana Gordon; Diana Corona‐Mata; José María Moyano; Ángela Peralbo‐Mo...; Ángela Camacho; Ignacio Pérez‐Valero; María del Mar Mal...; Antonio Rivero
• Keywords: Steatosis; Proteome

ABSTRACT Introduction Liver steatosis (LS) is a condition that characterised by hepatic fat accumulation unrelated to significant alcohol consumption. This study explored the serum proteomic profile associated with LS in people living HIV (PLWH). Methods The cohort comprised 266 PLWH, 21.1% and 78.9% of whom had no LS, respectively. Serum samples were analysed using liquid chromatography coupled mass spectrometry (LC–MS). Results Among 220 proteins detected, afamin (AFM) apolipoprotein F (APOF) identified as LS. Differential expression AFM APOF was observed under‐ normoweight patients, emphasising their potential biomarkers patients without overweight or obesity. Conclusions These findings suggest could serve promising paving way for further investigations into roles these development this unique population.