The deleterious impacts of dietary titanium dioxide nanoparticles on the intestinal microbiota, antioxidant enzymes, diseases resistances and immune response of Nile tilapia

• DOI: 10.1111/are.15539
• Publication Date: 2021-08-29T07:34:42Z
• Authors: Ahmed H. Sherif; Mohamed El‐Sayed ...; Salma I. El‐Saman...; Ahmed Seida; Nader M. Sabry; Mohamed Eldawoudy; Mohamed Abdelsalam; Nehal A. Younis
• Keywords: Nile tilapia

Titanium dioxide nanoparticles (TiO2 NPs) are used in numerous products, such as paints, pharmaceuticals, environmental sanitizing agents and even a whitening food additive (E171). Residual TiO2 NPs considered among the emerging contaminants of aquatic environments. However, effect exposure on intestinal microbiota population, microbial disease resistance immune-related gene expression Nile tilapia (Oreochromis niloticus) is largely obscure. Three groups fish were nurtured diets containing 1 mg/ml with three different sizes (53, 31 13 nm), beside control group for four weeks before sampling tissues. Fish fed TiO2NPs showed significantly increased higher levels tumour necrosis factor (TNF-α), interleukin (IL-6) IL-1β, along insignificant changes IL-8 IL-10 compared group. These indicate strong inflammatory response. Treated marked decrease count some microbiota, aeromonas, pseudomonas lactobacillus. challenged against A. hydrophila, mortality rate was observed smaller (13 nm). The antioxidant enzymes catalase, glutathione peroxidase superoxide dismutase NPs, while metallothionein only slightly changed. In conclusion, feeding nm) 4 alters population provides additional information toxic impacts health immune status O. niloticus.