Effects of berberine on the growth performance, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers

• DOI: 10.1111/asj.13255
• Publication Date: 2019-07-02T05:08:36Z
• Authors: Li Yang; Gang Liu; Xiaorui Liang; Mengmeng Wang; Xiaoqing Zhu; Yan Luo; Yunxia Shang; Jing‐quan Yang; Ping Zhou; Xin‐Li Gu
• Keywords: Malondialdehyde

Abstract This study evaluated the effects of berberine on growth performance, immunity, haematological parameters, antioxidant capacity, and expression immune response‐related genes in lipopolysaccharide (LPS)‐challenged broilers. We assigned 120 one‐day‐old male broilers (Ross 308) to two treatment groups; each group included subgroups, which six replicates five birds per replicate. The experiment used a 2 × factorial arrangement with (0 or 60 mg/kg dietary) challenge status [injection saline (9 g/L w/v) LPS (1.5 body weight)] as main factors. On days 14, 16, 18 20, were intraperitoneally injected physiological saline. Blood liver samples collected day 21. Dietary supplementation significantly alleviated compromised average daily gain feed intake ( p < 0.05) caused by LPS. led increased lymphocyte white blood cell (WBC) counts, malondialdehyde (serum liver) content, immunoglobulin G M, tumour necrosis factor‐α (TNF‐α) interleukin‐1β (IL‐1β) reduced serum total superoxide dismutase (T‐SOD) activity 0.05). mitigated LPS‐induced decreases mRNA nuclear factor‐kappa B (NF‐κB), TNF‐α, IL‐1β, inducible nitrite synthase cyclooxygenase‐2 liver. In conclusion, has positive effect challenge, may be related increase enzyme inhibition both NF‐κB signalling inflammatory mediators.