Risk Factors for Mortality and Endotracheal Intubation after Methadone Intoxication

• DOI: 10.1111/bcpt.12476
• Publication Date: 2015-08-24T16:46:07Z
• Authors: Hossein Hassanian...; Kambiz Soltaninejad; Shahin Shadnia; Ali Kabir; Mitra Movahedi; Amirhossein Mirafzal
• Keywords: Drug overdose; Opioid Overdose

Abstract This was a retrospective chart review to evaluate various risk factors associated with in‐hospital mortality and intubation in acute methadone overdose. All patients admitted an academic hospital Tehran, Iran, during 10‐year period (2000–2009) constituted the study sample. Exclusion criteria were significant comorbidities age under 18 years. Outcome variables being intubated admission. A total of 802 enrolled study. There 15 (1.8%) deaths due overdose or its complications. The number yearly admissions 2000, 16 2001, 2002, 2003, 23 2004, 38 2005, 59 2006, 110 2007, 206 2008 301 2009. Based on logistic regression analysis, most important independent variable predicting length admission toxicology ward [ OR (95% CI ): 1.6 (1.1–2.3)]. For prediction intubation, Glasgow Coma Scale ( GCS ) score 5–9 356.5 (9.8–12907.4)] emergency department ED ), miosis [356.9 (1.4–87872.5)] respiratory rate [1.5 (1.1–2.1)]. Linear model for hospitalization showed patient as this outcome. Despite relatively low rate, increasing methadone‐poisoned requires special attention common intoxication. Careful disposition from ordinary wards intensive care units also higher lower levels should be considered