Impact of the Chronic Omega‐3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6‐Hydroxydopamine in Rats

• DOI: 10.1111/bcpt.12713
• Publication Date: 2016-11-24T15:02:45Z
• Authors: Alexandre Sales B...; Rafael Yuri Gouve...; Juliana Uchoa Cav...; Ricardo Basto Souza; Jonatas Cavalcant...; Gerardo Cristino ...; Mirna Marques Bez...; Thales Fontenele ...; Silvânia Maria Me...; Danielle Silveira...; Glauce Socorro de...; Lissiana Magna Va...
• Keywords: Neurochemical; Hydroxydopamine

Parkinson's disease (PD) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra. The neuronal may result from convergence number different pathogenic factors, including apoptosis, excitotoxicity and oxidative stress. Many studies emphasize importance omega-3 polyunsaturated fatty acids (ω-3 PUFAs) vital processes such as maintenance properties cell membranes participation signal transduction biodynamic activity membranes. In this study, protective effect ω-3 PUFA administration on 6-hydroxydopamine (6-OHDA) model PD rats was investigated. (1.5 3.0 g/kg) orally administered gavage during 28 consecutive days to male Wistar rats. On 4th day, hemiparkinsonism induced through intrastriatal injection 6-OHDA. 25th animals were submitted behavioural analysis. 28th after euthanasia, brain areas collected for neurochemical evaluation. PUFAs restored monoamine amino acid levels striatum hemiparkinsonian rats, followed reduction apomorphine-induced rotations promotion partial locomotor recovery. addition, decreased lipid peroxidation nitrite Thus, study suggests that supplementation with prevents disturbances 6-OHDA, presenting potential neuroprotective action.