Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5

• DOI: 10.1111/bcpt.13736
• Publication Date: 2022-04-26T07:45:06Z
• Authors: Qingqing Zhang; Ruiying Yang; Yizhen Tian; Suyin Ge; Xiaojuan Nan; Shihao Zhu; Shuhong Dong; Baolai Zhang
• Keywords: Vascular Endothelial Growth Factor A; Mice; Protein-Arginine N-Methyltransferases; 03 medical and health sciences; 0302 clinical medicine; Ribavirin; Animals; Sarcoma; Arginine; Cell Proliferation; 3. Good health

Protein arginine methyltransferases 1 and 5 (PRMT1 PRMT5) are frequently overexpressed in diverse types of cancers correlate with poor prognosis, thus making these enzymes potential therapeutic targets. The aim this study was to assess elucidate the anti-tumour effect epigenetic regulatory mechanism ribavirin soft tissue sarcomas (STS). We showed that inhibited growth metastasis prolonged survival animals bearing STS cells by downregulating mRNA protein levels PRMT1/PRMT5 attenuating accumulation asymmetric symmetric di-methylation (ADMA SDMA). Furthermore, lowered permeability peritoneum KM mice S180 ascites via decreasing level vascular endothelial factor (VEGF). Ribavirin a potent inhibitor cell proliferation through downregulation both type I PRMT1 II PRMT5. could be used enhance efficacy doxorubicin allograft tumour models.