Characterisation of children and adolescents with acute lymphoblastic leukaemia who presented without peripheral blood blasts at diagnosis

• DOI: 10.1111/bjh.18552
• Publication Date: 2022-11-10T05:19:46Z
• Authors: David Spencer Mangum; Johnathon D. Bishop; Yinmei Zhou; Cheng Cheng; Seth E. Karol; Jeffrey E. Rubnitz; Raul C. Ribeiro; Jun J. Yang; Charles G. Mullighan; Sima Jeha; Ching‐Hon Pui; Hiroto Inaba
• Keywords: Childhood leukaemia; Hematology

Summary Of 1003 children with acute lymphoblastic leukaemia (ALL), 147 (14.7%) presented without peripheral blood blasts (PBB). While absence of PBB was not independently associated survival outcomes when compared to those PBB, patients had distinct genetic and clinical characteristics. Notably, we identified a novel genotype–phenotype relationship, in that the significantly higher incidence hyperdiploid B‐ALL, accounting for almost half all (46.9% vs. 22.7%, p < 0.001). Further, decreased rates involvement central nervous system (