Hypoxia‐mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion

• DOI: 10.1111/cas.12522
• Publication Date: 2014-09-01T05:24:04Z
• Authors: Nobuaki Fujikuni; Hideki Yamamoto; Kazuaki Tanabe; Yutaka Naito; Naoya Sakamoto; Yuka Tanaka; Kazuyoshi Yanagihara; Naohide Oue; Wataru Yasui; Hideki Ohdan
• Keywords: CD24; Hypoxia

CD24 is a heavily glycosylated cell surface protein that expressed in putative stem cells and overexpressed various human malignancies, yet the significant roles of gastric cancer development are still elusive. We investigated involvement aggressiveness, which attributed to its heterogeneity. Cultured showed diverse expression patterns CD24, whereas other defined markers, such as CD44 CD133, were homogenous. Purely sorted CD24-negative strong alteration into CD24-positive type an autochthonous manner, reached steady levels. Our clinicopathological study revealed positivity was independent prognostic factor both intestinal diffuse types cancer. correlated with advanced stages, invasiveness, lymph node metastasis Silencing cultured significantly decreased migration invasion. Hypoxic treatment upregulated expression, simultaneously induced motility invasion cells. treatment-induced attenuated by knockdown hypoxia-inducible transcription factors. These data suggest capable gaining invasiveness through induction mediated hypoxia. would be attractive marker define not only heterogeneity but also aggressiveness The mechanisms hypoxia induces potential therapeutic target for