Which infants with eczema are at risk of food allergy? Results from a population‐based cohort

• DOI: 10.1111/cea.12406
• Publication Date: 2014-09-11T13:21:13Z
• Authors: P. E. Martin; J. K. Eckert; J. J. Koplin; A. J. Lowe; L. C. Gurrin; S. C. Dharmage; P. Vuillermin; M. L. K. Tang; A.‐L. Ponsonby; M. Matheson; D. J. Hill; K. J. Allen
• Keywords: Oral food challenge; Egg allergy; Peanut Allergy

The relationship between early onset eczema and food allergy among infants has never been examined in a population-based sample using the gold standard for diagnosis, oral challenge.We characterised risk of challenge-proven with general population.One-year-old (n = 4453 meeting criteria this analysis) were assessed history eczema, received nurse-administered examination underwent skin prick testing to peanut, egg sesame. Those detectable wheal one test foods an challenge irrespective size. allergy, stratified by severity age onset, was estimated multivariate logistic regression population sampling weights.One five allergic white or sesame, compared twenty-five without (OR 6.2, 95% CI 4.9, 7.9, P < 0.001). prevalence peanut low absence (0.7% 0.4, 1.1). Infants 11.0 times more likely develop (95% 6.6, 18.6) 5.8 4.6, 7.4) 12 months than eczema. 50.8% 42.8, 58.9) (<3 months) who required doctor-prescribed topical corticosteroid treatment developed allergy.Eczema, across clinical spectrum infancy, is strong factor IgE-mediated allergy. six have 11 Our data suggest that heightened awareness healthcare practitioners treating especially if severe, warranted.