Food‐induced anaphylaxis in infancy compared to preschool age: A retrospective analysis

• DOI: 10.1111/cea.13519
• Publication Date: 2019-10-25T09:42:25Z
• Authors: Guillaume Pouessel; Charlotte Jean‐Bart; Antoine Deschildre; Xavier Van der Br...; Luciana Kase Tanno; Pascale Beaumont; Pascale Dumond; Dominique Saboura...; Etienne Beaudouin; Nassima Ramdane; Valérie Liabeuf; Jean‐Marie Renaudin
• Keywords: Discontinuation; Mucocutaneous zone

Abstract Objective Little is known regarding food anaphylaxis in infancy. We aimed to describe specificities of infants (≤12 months) as compared preschool children (1‐6 years). Methods conducted a retrospective study all cases recorded by the Allergy Vigilance Network from 2002 2018, focusing on infants. Results Of 1951 reactions, 61 (3%) occurred and 386 (20%) children. Two had two reactions; thus, we analyzed data among 59 (male: 51%; mean age: 6 months [SD: 2.9]); 31% history atopic dermatitis, 11% previous allergy. The main allergens were cow's milk (59%), hen's egg (20%), wheat (7%) peanut with (27%) cashew (23%) Anaphylaxis 28/61 (46%) at first intake after breastfeeding discontinuation. Clinical manifestations mainly mucocutaneous (79%), gastrointestinal (49%), respiratory (48%) cardiovascular (21%); 25% received adrenaline. Hives, hypotension neurologic symptoms more likely be reported than ( P = .02; .004; .002, respectively). Antihistamines corticosteroids often prescribed .005; .025, Conclusion Our found that presenting their allergy, setting high rate infant formula use, most predominant trigger was milk. As older children, hives, hypotonia believe this represents distinct phenotype can further support developing clinical criteria