Caesarean delivery and the risk of atopic dermatitis in children

• DOI: 10.1111/cea.13668
• Publication Date: 2020-05-21T06:50:00Z
• Authors: Megan Richards; Jeannette Ferber; Hong Chen; Erin Swor; Charles P. Quesen...; De‐Kun Li; Lyndsey A. Darrow
• Keywords: Caesarean delivery; Medical record

Caesarean delivery (C-section) may disrupt maternal-infant microbial transfer and alter immune system development subsequent risk for atopic dermatitis.Investigate the association between C-section dermatitis by age four examine potential sources of bias in relationship a large cohort study.Maternal child information was collected through Kaiser Permanente Northern California's (KPNC) integrated healthcare system. Data included electronic medical records, pharmacy databases, state birth prospectively breastfeeding surveys. Children were eligible if they born KPNC or contracting hospital 2005 2014 had continuous enrolment at least years (n = 173 105). Modified Poisson regression with robust variance estimation used to estimate overall when stratified demographic labour characteristics.Although unadjusted analyses showed positive [RR(95%CI): 1.06(1.03, 1.10)], this effect attenuated towards null after adjustment [aRR(95%CI): 1.02(0.99, 1.05)]. In analyses, there evidence that increased among certain subgroups (eg firstborns, overweight/obese pre-pregnancy BMI), but associations weak. conditions indicative exposure maternal microbiome (ie no labour, short interval membrane rupture delivery) dermatitis. Estimated not strongly influenced intrapartum antibiotics, breastfeeding, missing data, familial factors.Caesarean associated US cohort. This did appear be biased behaviour, indication, covariates, factors.