Alpha‐Gal Sensitization Dynamics in Individuals After Tick Bites With or Without Erythema Migrans

• DOI: 10.1111/cea.70011
• Publication Date: 2025-03-20T05:39:07Z
• Authors: Tamara van Gorkom; Michiel Heron; Agnetha Hofhuis; Carlijn Jongerius; Fiona R. M. van d...; Hanneke N. G. Oud...; Hein Sprong; Steven F. T. Thijsen; Kristin Kremer
• Keywords: Erythema migrans; Erythema; Erythema chronicum migrans

α-Gal syndrome (AGS) is an emerging tick-borne disease characterised by the development of specific immunoglobulin E (sIgE) antibodies against galactose-α-1,3-galactose (α-gal), a carbohydrate found in most mammalian species, but not humans. AGS occurs individuals with history tick bites. Currently, no data exist on α-gal sIgE seroprevalence Dutch population, including those bites or erythema migrans (EM). Therefore, this study aimed to determine rate assess seroconversion after bites, and relationship between EM serum. sensitisation rates were assessed (TB), EM, general population. Blood samples collected from TB- EM-cases at baseline again 3 months. Single blood controls selected population survey. In total, 156 TB-cases, 160 EM-cases, 316 included. 1.9% for 10.3% 19.1% baseline, respectively (cut-off sIgE: ≥ 0.10 kUA/L). Rates increased 17.9% comparable 16.9% months EM-development. Distinct observed over 3-month period. TB-cases showed rising rate, while had elevated both time points. This difference likely due timing bite, having recent bite developing days weeks post-bite. Both groups higher than controls, corroborating link sensitisation.