The correlation between T helper type 17 cells and clinical characters in Chinese paediatric patients with chronic hepatitis B

• DOI: 10.1111/cei.12028
• Publication Date: 2012-11-06T12:21:11Z
• Authors: S Zhu; H Zhang; Y Dong; Z Xu; D Chen; L Wang; Y Gan; F Wang; Y Wang; X Xing; S Hu; Z Li; L Long; L Liu; Y Zhong
• Keywords: Pathogenesis; Hepatitis B

Interleukin (IL)-17-mediated immune response has been shown to play a critical role in inflammation-associated disease. However, its the pathogenesis of chronic hepatitis B virus (HBV) paediatric patients remains unknown. We investigated frequency T helper type 17 (Th17) cells and evaluated association between Th17 clinical characters with (CHB). The was detected by flow cytometry analyses from 65 CHB nine healthy controls. degree hepatic inflammation graded using histological activity index (HAI). Compared controls, peripheral blood significantly higher CHB. proportion HAI score (G2-G3) compared those subjects lower (G0-G1), but had no correlation serum HBV DNA loads or alanine aminotransferase levels. younger age group (age 1-6 years), cell older 7-18 years). Peripheral is associated closely liver tissues