CCR6 defines a subset of activated memory T cells of Th17 potential in immune thrombocytopenia

• DOI: 10.1111/cei.13233
• Publication Date: 2018-11-07T10:18:29Z
• Authors: M Lyu; Y Li; Y Hao; C Lyu; Y Huang; B Sun; H Li; F Xue; X Liu; R Yang
• Keywords: Immunophenotyping

Summary Current researches have determined the significance of C-C chemokine receptor (CCR)6 expression as either a marker T helper cells (Th) or an effector and regulator cell function. However, roles CCR6 in pathogenesis immune thrombocytopenia (ITP) are unclear. In this study, we aimed to investigate phenotype functional characteristics circulating CCR6+ blood from chronic ITP patients healthy controls. We found that frequency CCR6+CD4+ was higher than Anti-CD3/anti-CD28 stimulation induced rapid expansion patients. had activated predominantly expressed CD45RO. Forkhead box protein P3 (FoxP3) CD25-positive were exclusively detected within cells. patients, regulatory (Treg) decreased positively correlated with platelet counts transforming growth factor (TGF)-β plasma levels. contrast CCR6– counterparts, produced levels interleukin (IL)-17A. The Th17 IL-17A supernatant. Most importantly, subpopulations, but not CCR6−CD4+, closely treatment response These findings suggest memory could be used monitor disease activity response.