Abdominal aortic aneurysm as an IgG4-related disease

• DOI: 10.1111/cei.13307
• Publication Date: 2019-04-29T12:45:20Z
• Authors: M Prucha; P Sedivy; P Stadler; P Zdrahal; P Prokopova; L Voska; L Sedlackova
• Keywords: Hypergammaglobulinemia; IgG4-Related Disease; Pathogenesis

Summary The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) regard immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised collection disorders characterized by IgG4 hypergammaglobulinemia, the presence IgG4-positive plasma cells in organs affected fibrotic or sclerotizing changes and typical histopathological features. It was identified as possible cause vasculitis large vessels. Studies have been published on association between inflammatory cardiovascular IgG4-RD. We examined 114 AAA requiring surgery order identify findings which are characteristic Aneurysm samples from seven showed features consistent IgG4+ cells. Only two these elevated serum levels higher 1·35 g/l. In five patients, concentration lower than 1·20 g/l, number being 50/high-power field. These heterogeneous group diseases different pathogenesis.