Region‐specific ischemia, neovascularization and macular oedema in treatment‐naïve proliferative diabetic retinopathy

• DOI: 10.1111/ceo.13168
• Publication Date: 2018-02-07T15:30:10Z
• Authors: Jason Lange; Majda Hadziahmetovic; Jingfa Zhang; Weiye Li
• Keywords: Ganglion cell layer

Abstract Importance Region‐specific pathology in proliferative diabetic retinopathy enhances our understanding and management of this disease. Background To investigate non‐perfusion, neovascularization macular oedema. Design A cross‐sectional, observational, non‐randomized study. Participants Consecutive 43 eyes 27 treatment‐naïve patients. Methods Ultra‐widefield fluorescein angiography for studying specific zones, that is, far‐peripheral zone, mid‐peripheral zone central retina (cr), spectral‐domain optical coherence tomography analysing thickness layers. Main Outcome Measures Non‐perfusion index (NPI) (NVI) different cr, retinal nerve fibre layer, ganglion cell layer (GCL), inner nuclear (INL) outer plexiform parafoveal regions. Results The NPI far‐periphery NVI mid‐periphery were the highest by one‐way analysis variance testing. Ischemic defined as high was significantly related to oedema via a binary classification approach ( P < 0.05). ischemic correlated with decreased both GCL 0.05); increased INL 0.0001). Conclusions Relevance region‐specific correlation mid‐periphery, but not thickness, suggests pathogeneses Retinal GCL, biomarkers neuronopathy, are associated ischemia, oedema, suggesting microangiopathy neuronopathy possess distinct pathogenic pathways. strong between indicates intracellular is determining factor