Dual Role of Exosomes in Parkinson's Disease: Adenine Exerts a Beneficial Effect

• DOI: 10.1111/cns.70331
• Publication Date: 2025-04-16T13:16:01Z
• Authors: Lei Chen; Yi‐Ting Shao; Ji Geng; Hua Liu; Qing‐Shan Liu; Yong Cheng; Ting Sun
• Keywords: Pars compacta; MPTP; Pathogenesis; Pathophysiology

ABSTRACT Aims Developing validated treatments for Parkinson's disease (PD) remains a priority clinicians and researchers. The lack of viable therapies may stem from an incomplete understanding PD pathogenesis inadequate therapeutic candidates. production transmission exosomes are gaining recognition in the neurodegenerative diseases. However, how affect pathophysiology has not been well elucidated. Methods Here, we investigated effect secreted by rats that were treated with saline or 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine hydrochloride (MPTP) treating healthy model mice, evaluated efficacy peripheral intracranial administration adenine, which is exosomal metabolite identified through widely targeted metabolomics. Results We found derived blood alleviated motor dysfunction, dopaminergic neuron loss substantia nigra pars compacta striatum, oxidative injury, neuroinflammation. Conversely, reproduced behavioral phenotype pathology mice. Additionally, adenine ameliorated coordination disorder loss, maintained homeostasis stress neuroinflammation activating cAMP/PKA signaling PD. Conclusion Together, these findings shed light on mechanism participate transmitting providing potential strategies.