Epstein‐Barr virus may contribute to the pathogenesis of adult‐onset recurrent respiratory papillomatosis: A preliminary study

• DOI: 10.1111/coa.13681
• Publication Date: 2020-12-02T21:45:28Z
• Authors: Martin Formánek; Debora Formánková; Pavel Hurník; Adéla Vrtková; Pavel Komínek
• Keywords: Recurrent Respiratory Papillomatosis; Pathogenesis; Cytomegalovirus; Varicella zoster virus

Human papillomavirus (HPV) causes adult-onset recurrent respiratory papillomatosis (AORRP), but AORPP prevalence is much lower than HPV prevalence. Thus, infection necessary, not sufficient, to cause AORRP and other factors likely contribute its pathogenesis. The present study aimed investigate whether co-infection with herpetic viruses may the pathogenesis of AORRP.Prospective case-control conducted from January 2018 November 2019.Tertiary referral centre.Eighteen consecutive patients 18 adults healthy laryngeal mucosa (control group) undergoing surgery.Cytomegalovirus, Epstein-Barr virus (EBV), herpes simplex 1 2, human herpesvirus 6, varicella zoster (including genotyping) were detected in biopsies papilloma or using real-time polymerase chain reaction reverse line blot. Dysplasia Ki67 levels determined specimens.EBV was 6 (33.3%) no control (P = .019). Presence dependent on tobacco exposure .413) genotype concentration > .999). EBV presence strongly related increased cell proliferation .005) number previous surgeries .039), dysplasia found 3 (16.7%) biopsies, one false positive. No found.Unlike viruses, seems interact HPV, enhancing contributing progression AORRP. Further research required elucidate specific interactions their role