Efficacy of providing energy expenditure information to guide weight loss interventions in people with obesity: A randomized controlled trial

• DOI: 10.1111/cob.12703
• Publication Date: 2024-09-17T18:13:35Z
• Authors: Jonathan Z. M. Lim; Andrew Williams; Jamie Burgess; James O'Connell; Michaela James; Andy Cross; David Hughes; Daniel J. Cuthber...; Uazman Alam; John P. H. Wilding
• Keywords: Respiratory quotient; Tolerability

Summary Resting energy expenditure (REE) and metabolic fuel utilization (carbohydrate or fat) proxied by respiratory quotient (RQ) from indirect calorimetry enables more precise measurement of needs fat oxidation capacity. The study compared the effectiveness providing information during diet exercise weight intervention versus standard care (SOC) on loss outcomes. Fifty‐two participants with obesity were recruited a specialist service, randomized 1:1 to (INT) SOC only. Participants in INT received four‐weekly dietetic counselling, using biofeedback data recommend caloric restriction physical activity goals, addition SOC. primary outcome was mean difference between both groups after 24 weeks. Secondary outcomes include participant acceptability tolerability calorimetry. group demonstrated additional (−2.3 kg [95% CI: −3.1, −1.5]; p <.001), reduced waist circumference (−3.9 cm −5.48, −2.26]; decreased body percentage (−1.5% CI:−2.31, −0.72], SOC, adjusting for baseline mass index, age, sex. Forty‐two percent (10/24) achieved minimum clinically significant threshold 5% baseline, 8% (2/26) ( = .007). Participant high, scores 4.5 ± 0.6 4.2 0.7 (5‐point Likert scale). establishes safety practical integration promoting improved self‐regulation enhancing loss.