Prognostic significance of apical lymph node metastasis in patients with node‐positive rectal cancer

• DOI: 10.1111/codi.12055
• Publication Date: 2012-10-11T17:43:24Z
• Authors: J. Peng; H. Wu; X. Li; W. Sheng; D. Huang; Z. Guan; M. Wang; S. Cai
• Keywords: T-stage; Univariate analysis

Abstract Aim The aim of this study was to assess the effect apical lymph node ( APN ) metastasis in predicting prognosis curatively treated node‐positive rectal cancer. We also investigated relationship between and total number metastatic nodes. Method A retrospective performed 510 patients with Clinicopathological variables, including status, were assessed univariate multivariate analyses. prognostic significance status patient outcomes American Joint Committee on Cancer AJCC N stage analysed. Results At a median follow up 47 months, 5‐year local recurrence LR rate, disease‐free survival DFS rate overall OS 18.3%, 55.5% 58.8%, respectively. 69.6% for no s (−)) 40.8% (+)). undetermined those (−) (+). Subgroup analysis gave 48.7% Stage N1 (+) 58.8% N2 P = 0.0004). Conclusion is an important factor cancer, which provides additional survival‐related classification irrespective stage. As usually outside radiation field, era multidisciplinary treatment its assessment should be incorporated into evaluation