Low faecal haemoglobin concentration potentially rules out significant colorectal disease

• DOI: 10.1111/codi.12087
• Publication Date: 2012-11-30T14:40:18Z
• Authors: P. J. McDonald; J. Digby; C. Innes; J. A. Strachan; F. A. Carey; R. J. C. Steele; C. G. Fraser
• Keywords: Colorectal cancer screening

The study aimed to determine whether faecal haemoglobin (Hb) concentration can assist in deciding who with lower abdominal symptoms will benefit from endoscopy.Faecal Hb concentrations were measured on single samples 280 patients referred for gastrointestinal tract endoscopy primary care NHS Tayside completed a immunochemical test (FIT) and underwent subsequent endoscopy.Among 739 invited patients, FIT by (median age 63 (18-84) years; 59.6% women), median time between of 9 days. Six (2.1%) participants had cancer, 23 (8.2%) high-risk adenoma (HRA) (more than three adenomas or any > 1 cm), 31 (11.1%) low-risk (LRA) 26 (9.3%) inflammatory bowel disease (IBD) as the most serious diagnosis. Those cancer 1000 ng Hb/ml buffer. + HRA IBD 75 buffer (95% CI 18-204), which was significantly higher that all remaining without significant colorectal (P < 0.0001). Using cut-off 50 buffer, negative predictive values 100.0%, 94.4%, 93.4% 93.9% found HRA, LRA IBD. Patients reasons referral other rectal bleeding family history did not have high concentrations.Faecal measurements considerable potential contribute reducing unnecessary majority symptomatic patients.