Major postoperative complications following elective resection for colorectal cancer decrease long‐term survival but not the time to recurrence

• DOI: 10.1111/codi.12757
• Publication Date: 2014-08-23T14:13:15Z
• Authors: M. Odermatt; D. Miskovic; K. Flashman; J. Khan; A. Senapati; D. O'Leary; M. Thompson; A. Parvaiz
• Keywords: Univariate analysis; Log-rank test

The aim of the study was to determine effect major complications after colorectal cancer surgery on survival and time recurrence.Patients having a curative resection follow-up at least 3 years were identified from prospective database. Major defined as Clavien-Dindo Grades 3b or 4 their impact recurrence mortality analysed by univariate multivariable analysis. Postoperative death within 30 days during initial hospitalization (Clavien-Dindo Grade 5) priori excluded.From 2003 2012, 868 resections resulting in 63 (7%) postoperative including deaths ≥ 3b) identified. After exclusion 5 (postoperative in-hospital deaths), 844 with 39 (5%) remained for Median 5.7 years. Using Kaplan-Meier method, estimated crude 5-year overall probability 78% (95% CI 75-81) group without 65% 51-83) (P = 0.009, log-rank test). significant negative predictor (hazard ratio 2.42, 95% 1.41-4.14) when adjusted sex, age, American Society Anesthesiologists grade, tumour site (colon vs rectum), R stage stage. However, both analysis, not 1.29, 0.56-2.99).Non-lethal seem have long-term but recurrence.