CD4+ T cell lymphopenia predicts mortality from Pneumocystis pneumonia in kidney transplant patients

• DOI: 10.1111/ctr.13877
• Publication Date: 2020-04-11T18:39:22Z
• Authors: Tilo Freiwald; Stefan Büttner; Nardos T. Cheru; Despina Avaniadi; Simon S. Martin; Christoph Stephan; Rainer U. Pliquett; Aida Asbe‐Vollkopf; Gundolf Schüttfort; Volkmar Jacobi; Eva Herrmann; Helmut Geiger; Ingeborg A. Hauser
• Keywords: Pneumocystis pneumonia; Univariate analysis

Abstract Background Pneumocystis jirovecii pneumonia (PcP) remains a life‐threatening opportunistic infection after solid organ transplantation, even in the era of prophylaxis. The association between risk developing PcP and low CD4 + T cell counts has been well established. However, it is unknown whether lymphopenia context post‐renal transplant increases mortality. Methods We carried out retrospective analysis cohort kidney patients with (n = 49) to determine factors for mortality associated PcP. correlated clinical demographic data outcome disease. For counts, we used Wilcoxon rank sum test in‐hospital Cox proportional‐hazards regression model 60‐day Results In univariate analyses, high CRP, neutrophils, lymphopenia, mechanical ventilation, acute injury network stage were following presentation receiver‐operator characteristic (ROC) analysis, an optimum cutoff ≤200 cells/µL predicted mortality, remained factor model. Conclusions Low count recipients biomarker disease severity