Advanced heart failure and heart transplantation in adult congenital heart disease in the current era

• DOI: 10.1111/ctr.14451
• Publication Date: 2021-08-08T19:39:51Z
• Authors: Angelo L. de la Rosa; Tahli Singer‐Englar; Rose O. Tompkins; Jignesh K. Patel; Jon A. Kobashigawa; Michelle M. Kittl...
• Keywords: Adult; Heart Defects, Congenital; Heart Failure; Survival Rate; 03 medical and health sciences; 0302 clinical medicine; Heart Transplantation; Humans; 3. Good health

AbstractBackgroundAdults with congenital heart disease (ACHD) may undergo heart transplantation (HTx) despite increased risk of poor short‐term outcomes due to factors including surgical complexity and antibody sensitization. We assessed the clinical characteristics and outcomes of patients with ACHD in the current era referred for HTx at a single high‐volume transplant center.MethodsFrom 2010 to 2020, 37 ACHD patients were evaluated for HTx. ACHD HTx recipients were compared to non‐ACHD HTx recipients matched for age, sex, listing status, and prior cardiac surgery.ResultsOf the 37 patients with ACHD, eight (21.6%) were declined for HTx. Of 29 ACHD patients listed, 19 (65.5%) underwent HTx. Compared with non‐ACHD HTx controls, the ACHD HTx recipients had more treated cellular (21.1% vs. 15.8%, P = .010) and antibody‐mediated (15.8% vs. 10.5%, P = .033) rejection. There was no difference in hospital readmission or allograft vasculopathy at 1 year. There was a nonsignificant higher 1‐year mortality in ACHD HTx recipients (21.1% vs. 7.9%, P = .21).ConclusionAt a high‐volume transplant center, ACHD patients undergoing HTx appear to have a marginally higher risk of rejection, but no significant increase in 1‐year mortality. With careful selection and management, HTx for patients with ACHD may be feasible in the current era.