Effect of donor pancreas extraction time on pancreas transplantation—a Swiss tertiary center experience

• DOI: 10.1111/ctr.14846
• Publication Date: 2022-11-02T20:34:41Z
• Authors: Fabian Rössler; Christoph Kümmerli; Sandro Hügli; Jan P. Jonas; Kerstin Hübel; Christian E. Ober...; Philip C. Müller; Olivier de Rougemont
• Keywords: Pancreas transplantation; Single Center; Clinical endpoint

We aimed to assess the effect of donor pancreas extraction time (ET) on postoperative complications and graft function after transplantation (PT). analyzed all consecutive procurements for simultaneous kidney (SPK) associated PT in a Swiss transplant center over 20-year period. Pancreas ET was defined as from cold flush static storage ice. The primary endpoint surgical complications. Secondary endpoints comprised (insulin-free survival) pancreatitis. Of 115 procured grafts median 65 min (IQR: 48-78 min). In multivariable analysis, did not negatively affect major (OR 1.41 [95% CI: .59-3.36]; p = .438) insulin-free survival (HR 1.42 .55-3.63]; .459). CIT 522 (441-608) min. with 2.51 1.11-5.68]; .027), but without impact 1.94 .84-4.48]; .119). Patients pancreatitis had no statistically significant differences (p .164 .47, respectively). Amylase levels > 270 U/L day 1 were significantly 3.61 1.06-12.32]; .040). Our results suggest that although found, shorter less can have positive Results could possibly be influenced by exceptional quality donors, short travel distances preservation times Switzerland.