The effect of primary renal disease upon outcomes after renal transplant

• DOI: 10.1111/ctr.15216
• Publication Date: 2024-03-07T11:27:30Z
• Authors: Shona Garland; Kairi Pullerits; Chukwuma A Chukwu; Rajkumar Chinnadurai; Rachel Middleton; Philip A Kalra
• Keywords: Primary (astronomy)

Abstract Background This study investigated whether nature of primary renal disease affects clinical outcomes after transplantation at a single center in the United Kingdom. Methods was retrospective cohort 961 transplant recipients followed up large from 2000 to 2020. Separation diseases responsible for end‐stage kidney included glomerulonephritis, diabetic disease, hypertensive nephropathy, autosomal dominant polycystic unknown cause, other causes and chronic pyelonephritis. Outcome data graft loss, cardiovascular events, malignancy, post‐transplant diabetes mellitus death, analyzed according type. Results The mean age 47.3 years. During follow‐up 7.6 years, 18% overall died corresponding an annualised mortality rate 2.3%. Death with functioning occurred 2.1% per annum, highest incidence observed patients (4.1%/year). Post‐transplant events 21% (2.8% year), again (5.1%/year) nephropathy (4.5%/year). manifested 19% annualized of2.1% while cancer stood 9% 1.1% . Graft loss 6.8% of1.2% year allograft injury, acute rejection recurrent glomerulonephritis being predominant causative factors. Median + IQR dialysis‐free survival whole 16.2 (9.9 ‐ > 20) shortest (11.0 years) greatest (18.2 .The collective decline eGFR over time ‐1.14ml/min/year. Recipients Pre‐transplant exhibited fastest decline(‐2.1ml/min/year) statistically significant difference comparison native Autosomal exhibiting lowest decline(‐0.05ml/min/year) Conclusion Primary can influence outcome transplantation, prior having poorest terms function. cause had best compared groups.