CAV Trajectories Among Patients With No or Mild CAV at 10 Years Posttransplant

• DOI: 10.1111/ctr.70009
• Publication Date: 2024-10-22T13:04:21Z
• Authors: Erin Harris; Nikil Prasad; Devin Skoll; Sambhavi Sneha Kumar; Justin Fried; Veli Topkara; Jayant K. Raikhelkar; Ersilia M. DeFili...; Farhana Latif; Melana Yuzefpolskaya; Paolo C. Colombo; Nir Uriel; Koji Takeda; Gabriel T. Sayer; Kevin J. Clerkin
• Keywords: Cardiac allograft vasculopathy

ABSTRACT Cardiac allograft vasculopathy (CAV) is a major cause of morbidity and mortality following heart transplantation (HT). Prior studies identified distinct CAV trajectories in the early post‐HT period with unique predictors, but evolution later periods not well‐described. This study assessed prevalence late progression associated risk factors HT recipients ISHLT 0/1 at 10 years post‐HT. Consecutive adult patients who underwent from January 2000 to December 2008 were evaluated grouped by into progressors (developed 2/3) or nonprogressors (remained 0/1). A total 130 included median age angiography 61.7 follow‐up time 4.8 years. 8.5% progressed 2/3, while remaining 91.5% nonprogressors. Progression was death retransplantation (27.3% [progressor] vs. 21.0% [nonprogressor], p = 0.70). These data may inform shared decision‐making about screening.