β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery

• DOI: 10.1111/cts.13178
• Publication Date: 2021-10-29T10:36:20Z
• Authors: Leanne Dumeny; Marut Chantra; Taimour Langaee; Benjamin Q. Duong; Daniel H. Zambrano; Frank Han; Dalia Lopez‐Colon; James F. Humma; Jonathan Dacosta; Tommie Lovato; Connie Mei; Julio D. Duarte; Julie A. Johnson; Giles J. Peek; Jeffrey P. Jacobs; Mark S. Bleiweis; Larisa H. Cavallari
• Keywords: Adult; Male; Polymorphism, Genetic; Genotype; Research; 05 social sciences; Infant; RM1-950; 3. Good health; Electrocardiography; Tachycardia, Ectopic Junctional; Humans; Female; 0501 psychology and cognitive sciences; Therapeutics. Pharmacology; Public aspects of medicine; RA1-1270; Cardiac Surgical Procedures; Child

Junctional ectopic tachycardia (JET) is a potentially life-threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to morbidity for at-risk populations. In adults, β1-adrenergic receptor (ADRB1) β2-adrenergic (ADRB2) genotypes have been associated increased risk arrhythmias. However, their association unknown. We aimed test associations between ADRB1 ADRB2 JET patients defects. Children who underwent cardiac surgery were genotyped the p.Ser49Gly (rs1801252; c.145A>G), p.Arg389Gly (rs1801253; c.1165C>G), p.Arg16Gly (rs1042713; c.46A>G), p.Glu27Gln (rs1042714; c.79G>C) polymorphisms. The occurrence of was assessed via cardiologist-interpreted electrocardiograms. Genotype analyzed logistic regression, adjusted clinical variables JET, separate analysis not on β-blocker. Of 343 included (median age 8 months, 53% boys, 69% European ancestry), 45 (13%) developed JET. Arg389Arg genotype overall population (odds ratio [OR] = 1.96, 95% confidence interval [CI] 0.96-4.03, p 0.064), but nominally taking β-blocker (n 324, OR 2.25, CI 1.05-4.80. 0.034). None other variants These data suggest that may predict following pediatric absence β-blockade. Whether treatment ameliorates this requires further research.