A Cutaneous Vascular Neoplasm With an EWSR1‐NFATC2 Translocation—Contributing to the Spectrum of Vascular Lesions Characterized by NFATC‐Related Fusions

• DOI: 10.1111/cup.14800
• Publication Date: 2025-03-11T15:32:14Z
• Authors: B. Schurink; A. M. van Huizen; C. D. Savci‐Heijink; E.‐J. Kooi

ABSTRACTRecently, a distinct subgroup of vascular neoplasms has been identified, characterized by NFATC‐related fusions. Although existing literature is limited, these lesions histologically show a variable appearance with a tendency for local recurrence but not distant spread. Therefore, they likely fall within the “benign” or at most in the “local aggressive”/“borderline” tumor category according to the International Society for the Study of Vascular Anomalies (ISSVA) classification scheme. Up to now, vascular tumors with NFATC‐related fusions have only been documented in bone and occasionally soft tissue. We present a case of a woman with a “difficult‐to‐diagnose” multifocal cutaneous vascular neoplasm showing an EWSR1::NFATC2 translocation. To our knowledge, this is the first report on a vascular neoplasm with an EWSR1::NFATC2 translocation occurring in the skin.