A randomized crossover study to assess the effect of an oat‐rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes

• DOI: 10.1111/dme.12228
• Publication Date: 2013-05-14T04:57:09Z
• Authors: S. C. McGeoch; A. M. Johnstone; G. E. Lobley; J. Adamson; K. Hickson; G. Holtrop; C. Fyfe; L. F. Clark; D. W. M. Pearson; P. Abraham; I. L. Megson; S. M. MacRury
• Keywords: Crossover study

Abstract Aims In the UK , lifestyle intervention is first‐line management in Type 2 diabetes. It unclear what type of diet most efficacious for improving glycaemic control. This study investigated effects an oat‐enriched on control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice. Methods a randomized crossover design, 27 volunteers diabetes, managed only, were observed two consecutive 8‐week periods following either or re‐enforced Volunteers attended at baseline (habitual intake) 8 16 weeks. Measurements included basic clinical measurements fasted (3‐h) glucose insulin response to healthy test meal. Markers stress, including high‐sensitivity C‐reactive protein, interleukin 6, 18, tumour necrosis factor‐alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL urinary isoprostanes, also measured fasting period. Results There no diet‐related control insulinaemic responses Total cholesterol (5.1 ± 1.0 vs. 4.9 0.8 mmol/l, P = 0.019) concentrations declined was decline adiponectin concentration ( 0.009), but effect intervention. None measures altered by Conclusion The had modest impact lipid lowering, did not these