Lichen planus and lichen planopilaris flare after COVID ‐19 vaccination

• DOI: 10.1111/dth.15283
• Publication Date: 2021-12-25T02:43:14Z
• Authors: Reem Diab; Farnaz Araghi; Mehdi Gheisari; Zahra Asadi Kani; Hamideh Moravvej
• Keywords: 03 medical and health sciences; COVID-19 Vaccines; 0302 clinical medicine; SARS-CoV-2; Vaccination; Lichen Planus; COVID-19; Humans; Female; Middle Aged; 3. Good health

We report two cases of lichen planus following COVID-19 vaccination in middle-aged women, where the first patient presented with lichenplanopilaris (LPP) relapse and development 14 days after second dose AstraZeneca vaccine, other who had a previous scattered lesion LP which extended increased severity Sinopharm. The suggested cause could be due to immune dysregulation up regulation T cell lymphocytes was triggered vaccination. What supports our hypothesis that occurred vaccination, is one patients responded successfully Metronidazole. This means infection process aggravating LP. To add, mechanisms for appearance or reactivation dormant LPP can cytotoxic CD8 T-lymphocytes increase secretion IFN-γ IL-5 cytokines may also result basal keratinocytes' apoptosis leading cutaneous manifestations. supported by efficacy Tofacitinib used addition decrease number infiltration adjust IFN expression.