Diastolic function as an early marker for systolic dysfunction and all‐cause mortality among cancer patients

• DOI: 10.1111/echo.15012
• Publication Date: 2021-03-14T08:04:25Z
• Authors: Joshua H. Arnold; Zach Rozenbaum; Aviram Hochstadt; Roni Rosen; Chen Sherez; Ayelet Sivan; Liat Mor; Yonatan Moshkovits; Ben Sadeh; Ofer Havakuk; Assi Milwidsky; Sivan Shamai; Svetlana Sirota D...; Yaron Arbel; Yan Topilsky; Michal Laufer‐Perl
• Keywords: Interquartile range; Subclinical infection; Cardiotoxicity; Systole

Abstract Background Increased survival among active cancer patients exposes a wide range of side effects, including cardiotoxicity, manifested by systolic dysfunction and associated with morbidity mortality. Early diagnosis subclinical function changes cardiac damage is essential in the management these patients. Diastolic considered common patients; however, its effect on or mortality still unknown. Methods Data were collected as part Israel Cardio‐Oncology Registry, enrolling prospectively following all evaluated cardio‐oncology clinic Tel Aviv Sourasky Medical Center. All underwent echocardiographic examinations evaluation diastolic parameters global longitudinal strain (GLS). Systolic was defined either an absolute reduction >10% left ventricular ejection fraction to value below 53% GLS relative between 1st 3rd echocardiography examinations. Results Overall, 190 included, mean age 58 ± 15 years female predominance (78%). During median follow‐up 243 days (interquartile ranges [IQR]: 164‐401 days), 62 (33%) developed dysfunction. Over 789 (IQR: 521‐968 29 (15%) died. There no significant differences baseline risk factors groups. Using multivariate analysis, E / e ′ lateral emerged significantly development all‐cause ( P = .015). Conclusion Among patients, may provide early marker for dysfunction, well