Stent‐induced tracheal stenosis can be predicted by IL‐8 expression in rabbits

• DOI: 10.1111/eci.12706
• Publication Date: 2016-11-22T05:38:46Z
• Authors: Elena Arellano‐Orden; Carolina Serrano; Ana Montes‐Worboys; Verónica Sánchez‐...; Alicia Laborda; Fernando Lostalé; Celia Lahuerta; Francisco Rodrígu...; Miguel Ángel de G...
• Keywords: Granulation tissue; Venous blood; Bare-metal stent

Abstract Background Bare metal stents may cause complications like fibrous encapsulation, granulation and tracheal stenosis. We investigated the behaviour of three commercially available in vivo (rabbits) vitro (coculture those with epithelial fibroblast cell lines). Also, we whether development stenosis could be predicted by any biological marker. Materials methods The tracheae 30 rabbits were implanted either nitinol stents, or without paclitaxel elution, a cobalt‐based stent. An additional ten underwent mock implantation (controls). Serial peripheral venous blood samples taken throughout study, several cytokines measured. Animals euthanized on day 90, immediate endoscopy lavage performed, then necropsy. Results Rabbits stent exhibited more inflammation highest incidence, reduced survival. Both vitro, this induced higher IL ‐8 levels than stents. Most important, presence stent‐induced was closely associated to increase expression just 1 after implantation: 1·19‐fold vs. baseline had 83% sensitivity, specificity, 77% positive predictive value, 88% negative value accuracy predict Conclusions incidence On other hand, paclitaxel‐eluting did not prevent provoked marked reaction compared bare Early rabbits.