High mortality in COVID‐19 patients with mild respiratory disease

• DOI: 10.1111/eci.13314
• Publication Date: 2020-06-14T19:48:25Z
• Authors: Chiara Masetti; Elena Generali; Francesca Colapietro; Antonio Voza; Maurizio Cecconi; Antonio Messina; Paolo Omodei; Claudio Angelini; Michele Ciccarelli; Salvatore Badalam...; G. Walter Canonica; Ana Lleo; Alessio Aghemo
• Keywords: Univariate analysis

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 189 000 people in Italy, with more than 25 deaths. Several predictive factors of mortality have been identified; however, none validated patients presenting mild disease.Patients a diagnosis interstitial pneumonia caused by SARS-CoV-2, symptoms, and requiring hospitalization non-intensive care unit known discharge status were prospectively collected retrospectively analysed. Demographical, clinical biochemical parameters recorded, as need for non-invasive mechanical ventilation admission intensive unit. Univariate multivariate logistic regression analyses used to identify independent predictors death.Between 28 February 10 April 2020, 229 consecutive included the study cohort; majority males mean age 60 years. 54% had at least one comorbidity, hypertension being most commonly represented, followed diabetes mellitus. 196 discharged after 9 days, while 14.4% died during because failure. Age higher 75 years, low platelet count (<150 × 103 /mm3 ) ferritin levels (>750 ng/mL) death. Comorbidities not independently associated in-hospital mortality.In-hospital COVID-19 symptoms is high older age, levels. Identifying early outcome can be useful practice better stratify manage COVID-19.