Efficacy of isatuximab in combination with steroids for the treatment of relapsed/refractory multiple myeloma patients exhibiting only biochemical progression—A single center retrospective study

• DOI: 10.1111/ejh.14057
• Publication Date: 2023-07-24T07:30:16Z
• Authors: Bernard Sean Regidor; Scott Jew; Marissa‐Skye Gold...; Bethany Marie Beatty; Sean Bujarski; Adam ElSayed; Ryan Danis; Susanna Kim; Regina Swift; Gary Schwartz; James R. Berenson
• Keywords: Antineoplastic Combined Chemotherapy Protocols; Humans; Steroids; Neoplasm Recurrence, Local; Multiple Myeloma; Dexamethasone; 3. Good health; Retrospective Studies

AbstractObjectivesIsatuximab is approved for treatment of relapsed/refractory multiple myeloma (RRMM) with dexamethasone and carfilzomib or pomalidomide. Patients receiving these three‐drug regimens have exhibited more Grade ≥ 3 adverse events (AEs) compared to the two‐drug class combination of isatuximab and steroids alone. Thus, this single‐center retrospective study investigated the efficacy of isatuximab with dexamethasone and methylprednisolone (ISAdm) for RRMM patients showing only biochemical progression (BP) of their disease.MethodsTwenty‐four RRMM patients exhibiting only BP were administered isatuximab at 10 mg/kg with dexamethasone once weekly for cycle 1 of a 28‐day cycle, followed by every other week for each cycle thereafter. Starting in cycle 2, oral methylprednisolone was added every other day stopping 48 h before and starting 48 h after each dexamethasone infusion.ResultsOverall response rate and clinical benefit rate were 63% and 79%, respectively. Progression free survival was 12.9 months. There were only 5 AEs of Grade ≥ 3 which included lymphocytopenia (13%), leukopenia (4%), and neutropenia (4%). No Grade ≥ 3 AE related to respiratory infection, anemia, or thrombocytopenia were reported.ConclusionThis study shows that the two‐drug class combination of ISAdm is an effective and well tolerated treatment option for RRMM patients exhibiting only BP.