The impact of non‐motor symptoms on the quality of life of Parkinson's disease patients: a longitudinal study

• DOI: 10.1111/ene.12950
• Publication Date: 2016-01-25T05:32:42Z
• Authors: K. M. Prakash; N. V. Nadkarni; W.‐K. Lye; M.‐H. Yong; E.‐K. Tan
• Keywords: Apathy

Background and purpose Non‐motor symptoms ( NMS s) are common amongst patients with Parkinson's disease PD ); however, little is known about their influence on the health‐related quality of life (QoL) over a defined follow‐up period. The study was aimed to establish impact s QoL 2‐year Method A total 227 newly referred were prospectively recruited between 2013 2014. Non‐Motor Symptoms Scale used evaluate burden whilst assessed Disease Questionnaire‐39 items. Motor disabilities using Part III (motor) Unified Rating UPDRS m). Results mean age 64.37 (10.18) years; 59.9% males majority (89.0%) ethnic Chinese. Almost 65% unemployed 84.6% had attained no more than secondary level education. In univariate analysis, burden, age, gender, subsequent visit, Hoehn Yahr staging, duration m score individually predictive change in Questionnaire Summary Index from baseline visit. However, multivariate significantly predicted scores motor did not. Specifically, domains 2 (sleep/fatigue), 3 (mood/apathy) 5 (attention/memory) most change. Conclusion Unlike disabilities, particular sleep, mood attention, have significant