Non‐motor symptoms in early Parkinson's disease with different motor subtypes and their associations with quality of life

• DOI: 10.1111/ene.13803
• Publication Date: 2018-09-03T10:21:48Z
• Authors: X. Huang; S. Y.‐E. Ng; N. S.‐Y. Chia; F. Setiawan; K.‐Y. Tay; W.‐L. Au; E.‐K. Tan; L. C.‐S. Tan
• Keywords: Motor symptoms; Postural instability

Background and purpose The aim of this study was to examine non‐motor symptoms in different Parkinson's disease ( PD ) motor subtypes their associations with quality life (QoL). Methods A total 132 patients early comprehensive examinations symptom assessments were included. Motor classified based on Stebbins’ method. Non‐motor assessed by the Non‐Motor Symptom Scale NMSS validated more instruments, including Pittsburgh Sleep Quality Index PSQI Fatigue Severity FSS ). QoL measured Disease Questionnaire‐8. Results We identified 66 (50%) tremor‐dominant TD subtype, 47 (35.6%) postural instability gait disorder PIGD subtype 19 (14.4%) Intermediate subtype. By comparing scores, had severe sleep impairment fatigue (domain 2 score: 5.64 vs. 2.52, P < 0.001), urinary 7 6.96 3.48, = 0.005) overall 25.89 17.27, 0.031), compared Validation using again suggested that independently significantly 5.57 4.29, 0.020) 34.81 25.85, 0.003) Several significant QoL, among which 0.0001, partial r 0.273) explained largest proportion variability . Conclusions Patients impairment, disturbance most important factors affecting independent subtypes. Prompt identification treatment these may improve patients’ QoL.